Uric Acid, Blood and Urine
Uric acid is a byproduct of the breakdown of purine (used to build DNA), that is mainly removed from the body by the kidneys, and a small amount in the intestines. High levels of uric acid in the blood cause the formation of crystals that will deposit within soft tissues, mainly in the large toes (gout). High levels of uric acid in the urine cause the formation of stones, which can block the kidneys, ureters, or bladder. Low blood levels are seen in people with liver disease, lead toxicity, or Wilson's disease.
High blood levels are seen in people who have a diet high in purines, kidney disease, an under-active thyroid gland, chronic alcohol abuse, inherited diseases affecting purine use by the body, gout, cancer, chemotherapy, or due to an unknown cause. Low urine levels are seen in people with chronic alcohol abuse, kidney disease, and eclampsia. High urine levels are seen in people with gout, lead poisoning, a diet high in purines, cancer, and chemotherapy. There are many medications that can affect uric acid levels.
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