Thyroglobulin
(Tg)

Alternate Names

  • Thyrogen-Stimulated Thyroglobulin
  • Tumor Marker

Thyroglobulin is a protein released only by the thyroid gland that is transformed into thyroid hormone by the body. Thyroglobulin is produced by both normal thyroid cells and thyroid cancer cells, and levels are used as a tumor marker to diagnose thyroid cancer. Thyroglobulin levels are also used to monitor the effectiveness of surgery for the removal of cancer cells; low thyroglobin levels indicate the presence of very little thyroid cancer. Thyroglobulin levels will increase when the cancer recurs, and levels are an indication of the size and severity of the cancer. Thyroglobulin levels are not used alone to diagnose illness, since levels can also be increased following a normal thyroid exam or after a thyroid gland tissue biopsy is done. You will need hormone replacement therapy following surgical removal of the thyroid gland.

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