Somatomedin C and Insulin-Like Growth Factor
(Somatomedin C and Insulin-like Growth Factor)
- IGF BP (Insulin-Like Growth Factor Binding Proteins)
Growth factor is a hormone released by the pituitary gland which requires normal levels of somatomedins for proper use within the body. While all somatomedins can be measured, somatomedin C is the most commonly tested and is also known as Insulin-like Growth Factor (IGF-1). Measurement of somatomedin C is an indirect measurement of the amount of growth hormone, and is an accurate representation of GH levels with less variation during the day. GH and IGF-1 levels are comparable; when GH is low, somatomedin C will also be low. Low blood levels are seen in people with inactive growth hormone, delayed puberty, underactive pituitary gland, cirrhosis, cancer of the pituitary gland, or nutritional deficiencies; and can lead to dwarfism. High blood levels are seen in people with normal pregnancy, obesity, early puberty, or overactive pituitary glands; which can lead to gigantism or acromegaly.
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