Pregnanediol is a component of the hormone progesterone necessary for normal menstruation and fertility. High levels are seen after the egg is released by the ovaries. Pregnanediol levels are also measured during pregnancy, since the placenta releases this hormone and levels are used to monitor women with a history of premature delivery or any other difficulties maintaining a pregnancy. Pregnanediol levels are mainly used to determine adequate hormone levels when being treated for infertility. Either high or low levels are seen in breast or ovarian cancer. High levels seen in people with adrenal gland dysfunction; low levels are seen in women with preeclampsia (high blood pressure during pregnancy), death of their unborn baby, failure of the placenta, or when normal menstruation has stopped.
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