Plasminogen Activator Inhibitor-1

PAI-1 is a protein released by the liver necessary for controlling normal breakdown of blood clots formed as a response to injury or inflammation. High PAI-1 blood levels are seen in people with an increased number of blood clots from trauma, infection, diabetes mellitus (DM), and during normal pregnancy. PAI-1 blood levels are related to an increased risk for heart attack and CAD (coronary artery disease). Low blood levels are seen in people with conditions that cause an increase in bleeding, since clots will break down faster than normal. PAI-1 may interfere with the action of medications given to control increased clot formation.


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