Maternal Screen Testing
(Triple/Quad Screen)

Alternate Names

  • Double Test
  • Triple Test
  • Quad Test
  • Fully Integrated Screen Test

Maternal Screen Testing is made up of a number of prenatal blood or urine tests that are used to screen for genetic abnormalities such as neural or abdominal wall defects or Down syndrome. These Screens are usually performed on women who already have a child with genetic abnormalities, or pregnant women who are over the age of 35 with the associated risk of having a child with genetic abnormalities.

Double Test: HCG (Human Chorionic Gonadotropin); AFP (alpha-fetoprotein)

Triple Test: HCG; AFP; Estriol

Quadruple Test: HCG; AFP; Estriol; DIA (Dimeric Inhibin A)

Fully Integrated Screen Test: AFP; HCG; Estriol; PAPP-A (Pregnancy-Associated Plasma Protein); Fetal Nuchal Translucency

The Triple Test is the screen that is most commonly run, but it is only a screening tool and the results are not specific enough to diagnose the actual presence of a genetic disease. Triple Test results are more accurate when run during the second trimester. If results are positive for the possible presence of abnormalities, then follow-up tests will be done that are more specific to the disease. CVS (chorionic villus sampling) will be done during the first trimester; amniocentesis will be done during the second trimester.


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