Human Lymphocyte Antigen B27

Alternate Names

  • Human Leukocyte A Antigen
  • White Blood Cell Antigens
  • Histocampatability Leukocyte A Antigen

Antigens are substances foreign to the body that causes inflammation, an allergic response, or an immune response. There are four different subgroups of HLA-B27 that determine whether antigens are present on the surface of white blood cells. The presence, or absence, of these antigens is important for determining whether transplanted organs will be compatible with the recipient's tissue, in order to avoid rejection following transplant. HLA-B27 antigen detection is also important when blood transfusions are given, since the presence of antigens against the donor's blood will cause a shorter lifespan for platelets or red blood cells (RBCs).

High blood levels of HLA-B27 are also used to diagnose Reiter's syndrome (arthritis), Grave's disease, rheumatoid arthritis, psoriasis, multiple sclerosis (MS), myasthenia gravis (MG), or celiac disease (gluten intolerance).


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Posted 5 years ago
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what is a normal HLA-B27Ag?

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