Factor V-Leiden
(FVL)

Alternate Names

  • Mutation Analysis
  • Factor V-Leiden Mutation: Activated Protein C (APC) Resistance
  • Factor V R506Q
  • Prothrombin 20210 Mutation
  • PT G20210A
  • Factor II 20210
  • PT 20210

A common inherited gene mutation causes the normal Factor V blood clotting mechanism to be altered. This alteration decreases how quickly Factor V is broken down, and increase Factor V blood levels for longer periods of time than normal. This results in an increased tendency for abnormal clot formation, leading to the formation of blood clots in either the veins or arteries, which can cause pulmonary embolism, heart attack or stroke. Most people who have this gene will never experience a blood clotting problem.

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