Cryoglobulins are malformed proteins found in the blood that clump together when the temperature is low and unclump when the temperature rises. Cryoglobulins are found in the blood of people with the autoimmune diseases SLE (systemic lupus erythmatosis), or Sjogren's syndrome; cancers such as leukemia, lymphoma, or multiple myeloma; diseases of the liver; or infections such as mononucleosis or kidney infection following a strep infection.


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