- Total CK
- Creatine Phosphokinase
CK is an enzyme found in the highest amounts in muscles, the brain, and the heart. When muscles or nerves in the brain are damaged, blood levels of CK rise within a short time after the damage. CK can be further broken down into isoenzymes, and these isoenzymes are more specific to where the damage has occurred. CK-MB is very specific for acute heart attack, heart infection, or other heart disease. CK-MM is specific for injury to skeletal muscles either from trauma or from excessive exercise, surgery or chronic alcoholism. CK-BB is specific to brain tissue and nerve damage.
CK-MB levels begin to increase within a known period of time (3 to 6 hours), will rise to its highest level within a known period of time (12 to 24 hours), then begin to fall and return to normal within a known period of time (12 to 48 hours). There are many medications that can affect CK levels.
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