Complement Assay
(C3 and C4 Complement)

Alternate Names

  • C3
  • C4
  • Total Complement
  • Total Hemolytic Complement Activity

Complements are enzymes necessary for normal inflammatory response; and to fight infection and develop immunity against communicable diseases. There are 50 blood complements that have been identified; Complement 3 and Complement 4 are the two most frequently tested. Low blood levels are mainly seen in people with the autoimmune diseases RA (rheumatoid arthritis), Sjogren's syndrome, SLE (systemic lupus erythmatosis) or kidney damage due to SLE; anemia, liver disease; or acute (current) infections of the kidneys, heart, or blood vessels. High blood levels are seen in people with recent onset of a heart attack, rheumatic fever, or cancer.


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