Coagulating Factors Concentration
(Coagulation Factors)

Alternate Names

  • Factor Assays
  • Blood Clotting Factors
  • Clotting Factors: Factor I, Factor II, Factor V, Factor VII, Factor, VIII, Factor IX, Factor X, Factor XII

There are factors normally present in blood that regulate normal blood clotting. Abnormal levels of these factors are due to illness, disease, medications, or inherited diseases. Each factor is associated with a specific disease or condition.

Factor I (fibrinogen) is increased in acute severe illness which increases the risk of heart attack or stroke; levels are decreased in DIC (disseminated intravascular coagulation), liver disease, or from an inherited deficiency.

Factor II (prothrombin) levels are decreased due to vitamin K deficiency, liver disease, an inherited deficiency, or the therapeutic use of the medication Coumadin (a blood-thinner).

Factor V (proaccerline) levels are decreased in DIC, liver disease, or from the breakdown of fibrin.

Factor VII (proconvertin or stable factor) levels are decreased due to an inherited deficiency, vitamin K deficiency, liver disease, or the therapeutic use of the medication Coumadin (a blood-thinner).

Factor VIII (antihemophilic factor) levels are increased during pregnancy, stress or trauma, acute inflammation, or birth control pills; levels are decreased due to inherited deficiency (Hemophilia A) or DIC.

von Willebrand Factor levels are decreased due to an inherited deficiency (von Willebrand's disease) or leukemia.

Factor IX (Christmas Factor) levels are decreased due to inherited deficiency (Hemophilia B), liver or kidney disease, vitamin K deficiency, DIC, or the therapeutic use of the medication Coumadin (a blood-thinner).

Factor X (Stuart Factor) levels are decreased due to an inherited deficiency, liver disease, vitamin K deficiency, or the therapeutic use of the medication Coumadin (a blood-thinner).

Factor XII (Hageman factor) levels are decreased due to inherited deficiency, liver disease, or DIC.

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