Alternate Names

  • CHS
  • Pseudocholinesterase
  • Cholinesterase RBC
  • Red Cell Cholinesterase
  • Acetylcholinesterase

CHS is an enzyme that is necessary for the normal functioning of nerve cells. People with a family history of prolonged anesthesia or breathing difficulties following surgery should have their blood levels of pseudocholinesterase tested. The presence of pseudocholinesterase causes increased and prolonged effects of succinylcholine, a muscle relaxant that is commonly used during surgery.

Toxicity from pesticides containing phosphates will lead to low levels of cholinesterase; along with low albumin levels, chronic liver diseases, and malnutrition. When increased levels of cholinesterase are seen in amniotic fluid, there is the possibility of neural tube defects in the unborn baby.


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