Antithrombin III
(AT-III)

Alternate Names

  • Heparin Cofactor
  • Functional Antithrombin III Assay
  • Immunologic Antithrombin III
  • Serine Protease Inhibitor

AT-III is a protein that is produced in the liver and is important to normal blood clotting. Low blood levels of AT-III will result in increased blood clotting, and can be due to either inherited or acquired deficiencies of AT-III. Inherited deficiencies of AT-III can result in the formation of thrombosis in the veins in young people, while acquired AT-III deficiencies are the result of liver disease, disseminated intravascular coagulation (DIC), deep vein thrombosis (DVT), or cancer. High AT-III blood levels are seen in people with vitamin K deficiency, acute hepatitis, jaundice, or following kidney transplant.

Normal AT-III values may vary depending upon the lab.

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