Anti-SS-A (Ro); Anti-SS-B (La); and Anti-SS-C Antibody
(Anti-Ro; Anti-La; Sjogren's Antibodies)
Autoimmune diseases cause the body to attack itself, which leads to inflammation and results in damage to muscles, tissues, and organs. The body produces antibodies specific to each autoimmune disease; the antibody levels measured in your blood are then used by your doctor to diagnose the disease that is causing your symptoms. Anti-SS-A, Anti-SS-B, and Anti-SS-C Antibodies are blood tests that are mainly used to diagnose Sjogren's syndrome, a disease process that results in extreme dryness of the mouth and eyes. Sjogren's syndrome can occur either alone or along with rheumatoid arthritis (RA) or SLE (systemic lupus erythmatosis).
There are three groups of tests used to diagnose Sjogren's syndrome and to monitor your response to treatment: Anti-SS-A (Ro) blood levels are high in people with Sjogren's syndrome, and high blood levels can also be seen in people with SLE; Anti-SS-B blood levels are high only in people with Sjogren's syndrome occurring by itself, and blood levels of this antibody are rarely elevated in people with SLE or rheumatoid arthritis; and Anti-SS-C blood levels are high in people with both Sjogren's syndrome and rheumatoid arthritis (RA).
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