Alkaline Phosphatase

Alternate Names


ALP is a liver and bone enzyme normally found in the blood. ALP levels are high in diseases of the liver and bone, and are very high in liver cancer. ALP is the best test to diagnose liver cancer that has metastasized from another location. ALP levels are also high in breast and prostate cancer that have metastasized to the bones, hyperparathyroidism, rheumatoid arthritis, and Paget's disease. ALP levels are also normally high whenever there is new bone growth, such as during adolescence or following a broken bone.

This test can be refined further by measuring the isoenzymes of ALP: ALP1 measures levels of liver enzymes, and ALP2 measures levels of bone enzymes.


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