Agglutinins, Febrile-Cold
(Febrile/Cold Agglutinins)

Alternate Names

  • Febrile Agglutinins
  • Cold Agglutinins

Infections cause certain antibody levels to increase in the bloodstream. Some antibodies will cause blood to clump at either a high temperature or a low temperature. The presence of Febrile Agglutinins is used to diagnose the infectious diseases brucellosis, rickettsial diseases, salmonellosis, and tularemia; also leukemia and lymphomas.

The presence of Cold Agglutinins is used to diagnose pneumonia caused by Mycoplasma pneumonia, influenza, lymphomas, mononucleosis, and rheumatoid arthritis. High agglutinin levels can interfere with blood type and cross and blood transfusions.


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