Adrenocorticotropic Hormone Stimulation Test with Metyrapone
(ACTH Stimulation Test with Metyrapone)
- Metyrapone Test
ACTH Stimulation Test with metyrapone is either a blood test or three consecutive 24-hour urine collections that is used to measure precursors of cortisol (steroid) levels in people who have been found to have adrenal insufficiency. You will be given the medication metyrapone, which blocks the production of cortisol by the adrenal glands. Falling cortisol levels should cause the pituitary gland to secrete more ACTH, and cortisol precursors can then be measured in either your blood or urine. The pituitary gland is abnormal and adrenal glands are normal if very high levels of cortisol precursors are measured after administration of metyrapone. The adrenal glands are abnormal if cortisol levels do not increase after administration of metyrapone, which indicates Cushing's syndrome caused by cancer of the adrenal glands.
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