(2, 3-Diphosphoglycerate)

Alternate Names

  • 2,3-DPG in Erythrocytes

2,3-DPG is a blood component that assists red blood cells (RBCs) in the transport of oxygen to all the tissues of the body. When anemia occurs or lung diseases such as emphysema or cystic fibrosis, 2,3-DPG will normally increase in order to provide more oxygen to the tissues. An inherited enzyme deficiency results in malformed RBCs that die more quickly than normal. The normal response to increased oxygen requirements does not occur, and RBC oxygen transport is decreased. 2, 3-DPG levels are mainly used to diagnose anemia.


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